CAS No.: 28957-04-2
冬凌草甲素 Catalog No. CSN19419
Synonyms: NSC-250682;Isodonol;冬凌草甲素
Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. Oridonin interacts with the cysteine 279 of NLRP3 NACHT domain through a covalent bond, abolishes NLRP3-NEK7 interaction, and inhibits consequent activation of NLRP3 inflammasome.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Ikezoe T, Yang Y, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther. 2005 Apr;4(4):578-86.
- [2] Ikezoe T, Chen SS, et al. Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol. 2003 Oct;23(4):1187-93.
- [3] Lu Y, Sun Y, Zhu J, Yu L, Jiang X, Zhang J, Dong X, Ma B, Zhang Q. Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway. Cell Death Dis. 2018 Jan 11;9(1):15. doi: 10.1038/s41419-017-0031-6. PMID: 29323103; PMCID: PMC5849031.
- [4] Shi M, Lu XJ, Zhang J, et al. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016;7(16):22623-22631.
- [5] He H, Jiang H, Chen Y, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9(1):2550. Published 2018 Jun 29.
- [6] Huang H, Weng H, Dong B, Zhao P, Zhou H, Qu L. Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia. Sci Rep. 2017 Jan 27;7:41525. doi: 10.1038/srep41525. PMID: 28128329; PMCID: PMC5270248.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 28957-04-2 | 储存条件 |
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| 分子式 | C20H28O6 | 运输 | 蓝冰 | |||||||||||
| 分子量 | 364.43 | 别名 | NSC-250682;Isodonol;冬凌草甲素 | |||||||||||
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动物实验配方 |
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